Heparanase expression in invasive trophoblasts and acute vascular damage

Vascular Mimicry Expression in Invasive Ductal Carcinoma; A New Technique for Prospect of Aggressiveness

Background & Objective: In vascular (vasculogenic) mimicry (VM), tumoral cells mimic the endothelial cells and form the extracellular matrix-rich tubular networks. It has been proposed that VM is more extensive in aggressive tumors. This study was designed to investigate the rate of VM expression in the stromal cells of invasive ductal carcinoma (IDC) and to find its relationsh...

Upregulation of Endothelin-1/Endothelin A Receptor Expression Correlates with Heparanase Expression in Ovarian Carcinoma

Background: Heparanase and endothelin-1/endothelin A receptor (ET-1/ETAR) expressions increase in cancer. This condition enhances tumor progression and correlates with poor survival. Limited data are documented regarding the role of heparanase and ET-1/ETAR in epithelial ovarian cancer (EOC). We sought to characterize the correlation between heparanase and ET-1/ETAR in EOC.Methods: Thirty patie...

Heparanase and vascular endothelial growth factor expression in the progression of oral mucosal melanoma.

Oral mucosal melanoma is an aggressive neoplasm with poor prognosis. Heparanase is an endo-beta-d-glucuronidase, which cleaves heparan sulphate chains. The vascular endothelial growth factor (VEGF) is the most potent angiogenic mitogen and interaction with its receptor (VEGFR) has been associated with angiogenesis. We investigated the expression of these molecules in the progression of oral muc...

Matrix Metalloproteinase Expression in Cultured Canine Trophoblasts

CXCL12 Expression by Invasive Trophoblasts Induces the Specific Migration of CD16 Negative Human Natural Killer Cells

word count: 199. Total word count: 4,999. Short title: CXCL12 in CD16NK cells homing to human decidua. Scientific Heading: Chemokines. ¶ These authors contributed equally to the work presented. Copyright (c) 2003 American Society of Hematology Blood First Edition Paper, prepublished online May 1, 2003; DOI 10.1182/blood-2003-02-0517 only. For personal use at PENN STATE UNIVERSITY on February 23...